EIN Fact Sheet: Concise summary of EIN
publications, summary statistics, and diagnostic strategies. This White
Paper was designed for distribution to clinicians and pathologists in practice
environments in transition to EIN.
of EIN course notes. These notes cover many aspects of the
website in easily printable format. Revised January, 2008.
diagnosis library is a series of 50 endometria originally diagnosed in
the WHO hyperplasia system, which have been re-diagnosed using EIN
criteria. Formal computerized morphometry (D-Score) and long term
clinical followup are available.
The Endometrial Precancer Type Collection
is a group of histologic images presented with a variety of accompanying
specialized studies including clonal analysis, K-ras mutation studies,
computerized morphometric analysis, and subjective diagnoses (WHO) of a
panel of expert pathologists.
Image Library is a collection of PTEN immunohistochemical images along
with companion H&E stained slides. Retrieval by diagnosis, or
morphometric parameters is possible.
Course Material for:
the ASCP course EIN (Endometrial Intraepithelial Neoplasia) and Ambiguous Premalignant
Archived here at www.endometrium.org are
a Sylabus and a color handout with
Supplemental Data to Published Reports:
Mutter et al,
Altered PTEN expression as a diagnostic marker for the earliest
endometrial precancers. JNCI 92:924-931, 2000.
Mutter GL, Ince TA, Baak JPA, Kust G, Zhou X, Eng C. Molecular
identification of latent precancers in histologically normal
endometrium. Cancer Research 2001; 61 (11):4311-4314.
Mutter GL, Baak JP, Fitzgerald JT, Gray R, Neuberg D,
Kust GA et al. Global expression changes of constitutive and hormonally
regulated genes during endometrial neoplastic transformation. Gynecol
Oncol 2001; 83(2):177-185.
Zheng W, Baker
HE, and Mutter GL. Involution of PTEN-Null Endometrial Glands with
progestin therapy. Gynecol. Oncol: 2004.
Mutter GL, Zahrieh D, Liu C, Neuberg D, Finkelstein D, Baker HE et al.
Comparison of frozen and RNALater solid tissue storage methods for use
in RNA expression microarrays. BMC Genomics 2004; 5(1):88.
Data Files available from
Gene Expression Omnibus as accession number GSE1296.