Supplemental Data For:

Supplemental Materials for: Zheng W, Baker HE, and Mutter GL. Involution of PTEN-Null Endometrial Glands with progestin therapy. Gynecol. Oncol: 2004.

Contents:

  1. Photomicrographs of all 9 cases having involution of PTEN-Null glands upon progestin therapy.
  2. Concordance Table showing Original WHO diagnoses of studied cases, vs. diagnoses rendered using EIN criteria.
  3. Printable version of Supplemental Data (Adobe pdf File)

Photomicrographs of all 9 cases having involution of PTEN-Null glands upon progestin therapy.

PTEN Immunohistochemistry of Cases with Involuted Glands. PTEN-Null glands in pre-treatment panel (Asterix), which are no longer present following progestin therapy (post-Rx Panel)

 

Case F:        Pre-Rx         Post-Rx  

Case H:       Pre-Rx         Post-Rx  

Case J:        Pre-Rx        Post-Rx  

Case K:       Pre-Rx        Post-Rx  

Case M:     Pre-Rx        Post-Rx  

Case O:      Pre-Rx       Post-Rx  

Case R:      Pre-Rx       Post-Rx  

Case U:      Pre-Rx        Post-Rx  

Case X:      Pre-Rx       Post-Rx  

 

Concordance Table showing Original WHO diagnoses of studied cases, vs. diagnoses rendered using EIN criteria.

Patient

EIN Dx

WHODx

a

ein

ACH

b

anov

SH

c

ein

ACH

d

emp

CH

f

anov

ACH

h

ein

ACH

i

emp

SH

j

emp

ASH

k

se

CH

m

anov

ASH

o

ein

ACH

q

pe

SH

r

anov

ACH

t

se

SH

u

se

CH

x

ein

ASH

y

se

CH

 

    EIN schema Key:
    EIN=endometrial intraepithelial neoplasia
    ANOV=proliferative type endometrium
            (consistent with anovulatory cycle)
    EMP=endometrial polyp
    PE=proliferative endometrium
    SE=secretory endometrium

    WHO schema Key:
    ASH= atypical simple hyperplasia
    ACH= atypical complex hyperplasia
    CH= complex hyperplasia, no atypia
    SH = simple hyperplasia, no atypia

 

 

 

 

 

 

 

 

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