|
Supplemental Data For:
Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JPA, Lees J et al. Altered
PTEN expression as a diagnostic marker for the earliest endometrial precancers. J
Natl Cancer Inst 2000; 92:924-930.
Table
of Sequenced PTEN Mutations
|
GM #
|
Dx
|
Nucleotide
|
Codon
|
Base
Change
|
Amino
Acid Change
|
|
94-107
|
Cancer
|
401
|
134
|
DEL
T
|
FS
|
|
94-107
|
Precancer
|
401
|
134
|
DEL
T
|
FS
|
|
94-109
|
Cancer
|
9
|
3
|
del
C
|
FS
|
|
94-109
|
Cancer
|
12
|
4
|
del
C
|
FS
|
|
94-109
|
Precancer
|
9
|
3
|
del
C
|
FS
|
|
94-109
|
Precancer
|
12
|
4
|
del
C
|
FS
|
|
94-123
|
Cancer
|
324
|
142
|
CGG>TGG
|
R142W
|
|
94-123
|
Cancer
|
389
|
130
|
CGA>CAA
|
R130Q
|
|
94-123
|
Cancer
|
334
|
145
|
TTT>TGT
|
F145C
|
|
94-123
|
Cancer
|
509
|
170
|
AGT>ATT
|
S170I
|
|
94-123
|
Cancer
|
637
|
213
|
CCT>TCT
|
P213S
|
|
94-133
|
Cancer
|
388
|
130
|
CGA>GGA
|
R130G
|
|
94-154
|
Cancer
|
388
|
130
|
CGA>TGA
|
R130X
|
|
94-159
|
Cancer
|
388
|
130
|
CGA>GGA
|
R130G
|
|
94-165
|
Cancer
|
800
|
267
|
800
DEL A
|
FS
|
|
94-169
|
Cancer
|
98
|
33
|
ATT>ACT
|
I33T
|
|
94-169
|
Cancer
|
111
|
37
|
TTT>TTA
|
I33T
|
|
94-169
|
Precancer
|
98
|
33
|
ATT>ACT
|
I33T
|
|
94-169
|
Precancer
|
111
|
37
|
TTT>TTA
|
I33T
|
|
94-170
|
Cancer
|
208
|
70
|
IVS3
+ 13 DEL
|
L70F
|
|
94-170
|
Cancer
|
437
|
146
|
DEL
A
|
FS
|
|
94-170
|
Cancer
|
433
|
145
|
DEL
T
|
FS
|
|
94-170
|
Cancer
|
594
|
198
|
IVS
- 28 DL TA
|
Silent
Intronic
|
|
94-170
|
Precancer
|
594
|
198
|
IVS
- 28 DL TA
|
Silent
Intronic
|
|
94-170
|
Precancer
|
437
|
146
|
DEL
A
|
FS
|
|
94-170
|
Precancer
|
433
|
145
|
DEL
T
|
FS
|
|
94-170
|
Precancer
|
208
|
70
|
IVS3
+ 13 DEL
|
L70F
|
|
94-171
|
Cancer
|
492
|
165
|
IVS
+ 12 DEL A
|
Silent
Intronic
|
|
94-171
|
Cancer
|
795
|
265
|
795
DEL A
|
FS
|
|
94-171
|
Precancer
|
795
|
265
|
795
DEL A
|
FS
|
|
96-4
|
Cancer
|
52
|
18
|
GAG>TAG
|
E18X
|
|
96-4
|
Precancer
|
52
|
18
|
GAG>TAG
|
E18X
|
|
96-5
|
Cancer
|
632
|
211
|
INS
G
|
FS
|
|
96-5
|
Precancer
|
632
|
211
|
INS
G
|
FS
|
|
96-6
|
Cancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-6
|
Precancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-14
|
Cancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-14
|
Precancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-26
|
Cancer
|
388
|
130
|
CGA>GGA
|
R130G
|
|
96-26
|
Cancer
|
511
|
171
|
CAG>GAG
|
Q171E
|
|
96-26
|
Precancer
|
511
|
171
|
CAG>GAG
|
Q171E
|
|
96-26
|
Precancer
|
388
|
130
|
CGA>GGA
|
R130G
|
|
96-32
|
Cancer
|
492
|
165
|
IVS
5 - 38 DEL T'S
|
Intron-Exon
boundry
|
|
96-32
|
Precancer
|
492
|
165
|
IVS
5 - 38 DEL T'S
|
Intron-Exon
boundry
|
|
96-37
|
Cancer
|
32
|
11
|
AGA>ATA
|
R11I
|
|
96-37
|
Cancer
|
847
|
283
|
CCA>TCA
|
P283S
|
|
96-41
|
Cancer
|
429
|
143
|
DEL
A
|
FS
|
|
96-41
|
Precancer
|
429
|
143
|
DEL
A
|
FS
|
|
96-43
|
Cancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-43
|
Precancer
|
955
|
319
|
955-958
DEL ACTT
|
FS
|
|
96-51
|
Cancer
|
164
|
55
|
IVS
2-3 INS TA
|
exon-intron
boundry
|
|
96-51
|
Precancer
|
164
|
55
|
IVS
2-3 INS TA
|
exon-intron
boundry
|
|
96-62
|
Cancer
|
511
|
171
|
IVS
29 A>C
|
Silent
Intronic
|
|
96-69
|
Cancer
|
611
|
204
|
CCA>CAA
|
P204Q
|
|
96-70
|
Cancer
|
697
|
233
|
GCT>TGA
|
R233X
|
|
96-132
|
Cancer
|
278
|
93
|
CAT>CGT
|
H93R
|
|
96-150
|
Cancer
|
184
|
62
|
AAA>TAA
|
K62X
|
|
96-150
|
Precancer
|
184
|
62
|
AAA>TAA
|
K62X
|
|
96-158
|
Cancer
|
196
|
66
|
AAG>TAG
|
L66X
|
|
