Objective: Type collections
promote standardized classification by extrapolation from thoroughly
documented examples.
In this series of 93 endometria we used a concensus approach to classify lesions as precancers or non-precancers based upon
concordance results of at least two of three analytical methods: Clonal analysis,
Concensus
of four Pathologist Diagnoses, and Computerized Morphometric Analysis.
This was the original series used to propose Endometrial
Intraepithelial Neoplasia as a diagnostic entity with new criteria1,2.
Detailed Methods are available for those who are interested.
Data Included in the Precancer Type Collection:
1)Images of 93 areas of endometria from women who got endometrial cancer
2)Diagnostic classification (WHO hyperplasia)by 4 gynecologic pathologists
3)Diagnostic Classification by EIN criteria.
4)Clonal analysis results using X inactivation (HUMARA) or microsatellite
assays
5)Histomorphometry analysis by D-Score (D-Score <1 is generally an EIN)
3)K-ras mutation analysis
References:
1)Mutter GL, Baak JPA, Crum CP,
Richart RM, Faquin WC, Boynton KA. Endometrial precancer diagnosis by
histopathology, clonal analysis, and computerized morphometry. J.
Pathology 2000; 190:462-469.
2)Mutter,GL and the Endometrial
Collaborative Group. EIN: Will it bring order to chaos? Gynecologic
Oncology, 2000; 76:287-290.
