Details

Dx:

EIN

Report #:

Tissue:

Key

--------Genetics--------

Clonality:

Monoclonal

Clonal Method:

X Inactivation (HUMARA)

Kras:

Mutant

Features Shared with Cancer:

Tumor and this area inactivate same X chromosome, and share

same k-ras mutation

--------Morphology--------

By Computer:

D-score:

0.7

Volume Percentage Stroma:

62.1

By 4 Expert Pathologists

Diagnosis

Followup

Pathologist A:

sh (2)

Symptomatic (1)

Pathologist B:

sh (2)

Symptomatic (1)

Pathologist C:

other (1)

Repeat Bx (2)

Pathologist D:

sh (2)

Symptomatic (1)

Mean of 4 Path:

1.75

1.25

Comments:

This is judged to be a precancer because of monoclonal growth, and presence of a k-ras mutation

shared with carcinoma. The morphology alone is equivocal, however, and could be classified as

indeterminate on that basis alone.