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Background
Inactivation Rates
Lesion Progression
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Biomarker Use
Methods
Citations
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This site contains an image archive of PTEN-null
endometrial tissues, along with matched PTEN mutational data, morphometric
data from PTEN immunohistochemistry, and patient demographics.
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Background.
PTEN, a tumor suppressor gene which is hormonally regulated in the
endometrium.
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Inactivation
Rates:
Compromise of PTEN tumor suppressor gene function is the most common
genetic lesion seen in endometrial adenocarcinoma.
Examine rates of lost PTEN expression and mutation/LOH in endometria
of a variety of endometria classified by histotologic subtype.
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Lesion
Progression:
Loss of PTEN function occurs at initiation of endometrial
tumorigenesis, and can be used to track PTEN-null clones during
progression to carcinoma. See examples of changing PTEN-null
clone physical configuration beginning with normal proliferative
endometrium and ending with EIN. Morphometric analysis of PTEN
null clone structural features shows trends in changing gland
density and size during progression.
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Image
library:
demarcates histological distribution of affected glands in a variety of
endometrial diagnostic settings.
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Biomarker
Use: Uses of PTEN immunohistochemistry as a biomarker for
endometrial neoplasia
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Methods
for PTEN immunohistochemistry.
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Citations used to prepare this section. You can
also do a quick PubMed
search for papers about PTEN in the endometrium.
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